Name: Spicy Southern Chicken Spaghetti Casserole for Cozy Nights
Prep time: 15 min
Cook time: 30 min
Total time: 50 min
Ingredients: 2 cups Cooked Chicken (You can substitute ground turkey or shredded tofu for a lighter option.); 12 oz Spaghetti (Feel free to use penne or rotini instead.); 1 can Cream of Mushroom Soup (10.5 oz; switch to cream of celery for a different flavor profile.); 1 can Cream of Chicken Soup (10.5 oz; consider using a plant-based version for vegetarian option.); 1 can Diced Tomatoes with Green Chilies (10 oz; fresh tomatoes with chopped green chiles work well too.); 1.5 cups Shredded Cheddar Cheese (Monterey Jack or Pepper Jack can be used for a kick.); 0.5 cup Chopped Bell Peppers (Any color bell pepper will do.); 0.5 cup Chopped Onion (Substitute with shallots for milder taste.); 1 tsp Garlic Powder (Fresh garlic can be substituted in for a brighter taste.); 1 tsp Onion Powder (Optional for lighter taste.); 0.5 tsp Paprika (Swap with smoked paprika for extra punch.); 0.25 tsp Cayenne Pepper (Adjust according to spice preference.); Salt and Pepper (Customize to taste.); 2 tbsp Butter (Olive oil is a good alternative.); Non-stick Cooking Spray (Can be replaced with butter or oil for greasing.)

Jump to Recipe Print Recipe

There’s something about the aroma of Spicy Southern Chicken Spaghetti Casserole that instantly transports me to cozy gatherings filled with laughter and comfort. This dish is a harmonious blend of tender, shredded chicken and zesty spices, all enveloped in creamy goodness and spaghetti—a real crowd-pleaser that’s perfect for busy weeknights or potlucks. Not only can you whip it up in under an hour, but with just 15 minutes of prep time, it’s an uncomplicated way to bring some Southern charm to your dinner table. Plus, its cheesy crust and hearty flavors make it a meal everyone will love. Are you ready to dive into this delightful comfort food?

Why You’ll Crave This Casserole?

Comforting and Delicious: This Spicy Southern Chicken Spaghetti Casserole is the epitome of comfort food, perfectly blending flavors that warm the heart.

Easy to Prepare: With minimal prep required, this recipe is beginner-friendly and perfect for busy weeknights.

Crowd-Pleasing: It combines family-favorite ingredients, making it a hit at potlucks or family dinners.

Versatile Variations: Feel free to substitute proteins or add veggies to meet your dietary preferences, as you’d do in Cheesy Chicken Spinach or Sweet Spicy Hot dishes.

Saves Time: With creamy layers and a cheesy topping, this casserole is ready in under an hour, leaving you more time to unwind.

Irresistibly Cheesy: The gooey cheddar on top creates a mouthwatering crust that everyone will fight over!

Spicy Southern Chicken Spaghetti Casserole Ingredients

For the Casserole

Cooked Chicken (2 cups) – Provides the main protein base; you can substitute ground turkey or shredded tofu for a lighter option.
Spaghetti (12 oz) – Serves as the foundation of the casserole; feel free to use penne or rotini instead for a change of texture.
Cream of Mushroom Soup (1 can, 10.5 oz) – Adds creaminess and richness; switch to cream of celery for a different flavor profile.
Cream of Chicken Soup (1 can, 10.5 oz) – Complements the mushroom soup; consider using a plant-based version for a vegetarian alternative.
Diced Tomatoes with Green Chilies (1 can, 10 oz) – Offers acidity and a hint of spice; fresh tomatoes with chopped green chiles work well too.
Shredded Cheddar Cheese (1½ cups) – Provides a melty, gooey topping; Monterey Jack or Pepper Jack can be used for a kick.
Chopped Bell Peppers (½ cup) – Adds sweetness and crunch; any color bell pepper will do here!
Chopped Onion (½ cup) – Offers depth of flavor; substitute with shallots for a milder taste.
Garlic Powder (1 tsp) – Enhances flavor; fresh garlic can be substituted in for a brighter taste.
Onion Powder (1 tsp) – Adds a deeper onion flavor; optional, if you prefer a lighter taste.
Paprika (½ tsp) – Contributes color and mild smokiness; swap with smoked paprika for an extra punch.
Cayenne Pepper (¼ tsp) – Adds a nice kick; feel free to adjust for your spice preference.
Salt and Pepper – Essential for seasoning; customize to your taste.
Butter (2 tbsp) – Used to sauté vegetables for added flavor; olive oil is also a great alternative.
Non-stick Cooking Spray – Prevents sticking; can be replaced with butter or oil for greasing the dish.

This Spicy Southern Chicken Spaghetti Casserole is a fantastic way to share warmth and comfort with your loved ones!

Step‑by‑Step Instructions for Spicy Southern Chicken Spaghetti Casserole

Step 1: Preheat and Prepare
Begin by preheating your oven to 350°F (175°C). While the oven is heating up, grab a 9×13-inch baking dish and grease it generously with non-stick cooking spray or a little butter to prevent any sticking. This ensures your Spicy Southern Chicken Spaghetti Casserole comes out clean and perfect every time.

Step 2: Sauté the Vegetables
In a skilled skillet, melt 2 tablespoons of butter over medium heat. Add the chopped onions and bell peppers, sautéing for about 5 minutes until they are tender and fragrant. You’ll know they are ready when the onions turn translucent and the peppers soften—this will add a burst of flavor to your casserole.

Step 3: Combine the Mixture
In a large mixing bowl, combine 2 cups of cooked chicken, the sautéed vegetables, one can each of cream of mushroom and cream of chicken soups, and the can of diced tomatoes with green chilies. Sprinkle in the garlic powder, onion powder, paprika, cayenne pepper, salt, and pepper. Mix well, ensuring all ingredients are evenly coated in that creamy goodness.

Step 4: Add the Pasta
Gently fold in 12 ounces of cooked spaghetti into your mixture, taking care not to break the noodles. This step is crucial for your Spicy Southern Chicken Spaghetti Casserole, as it helps to distribute the sauce throughout the pasta, ensuring each bite is filled with flavor.

Step 5: Transfer to Baking Dish
Pour the hearty chicken and spaghetti mixture into the greased baking dish, spreading it out evenly to create a flat surface. The casserole should look colorful and inviting already! This will be the foundation for a deliciously cheesy topping.

Step 6: Add the Cheese
Now it’s time to layer on the goodness—sprinkle 1½ cups of shredded cheddar cheese evenly over the entire top of the casserole. This cheesy layer will melt beautifully and create a golden, gooey crust that adds a delightful texture to your Spicy Southern Chicken Spaghetti Casserole.

Step 7: Bake to Perfection
Place the baking dish in your preheated oven and bake for 25–30 minutes. You’ll know your casserole is ready when the cheese is bubbly and golden brown, filling your kitchen with an irresistible aroma.

Step 8: Let It Rest
Remove the casserole from the oven and allow it to rest for a few minutes before serving. This brief wait helps the layers to set, making it easier to slice and serve. The anticipation will be worth it as you dish up this flavorful Spicy Southern Chicken Spaghetti Casserole!

ndm2kjhd1pl298dwmqei

Spicy Southern Chicken Spaghetti Casserole Variations

Feel free to put your own spin on this beloved dish, making it even more delightful for your family!

Vegetarian Delight: Substitute the chicken with assorted vegetables like zucchini, mushrooms, and spinach for a wholesome vegetarian option. This twist keeps all the comforting flavors while catering to plant-based diets.
Cheese Swap: Try using Monterey Jack or Pepper Jack cheese instead of cheddar for an exciting flavor boost. The extra creaminess and warmth from these cheeses can take your casserole to a new level!
Extra Crunch: Top your casserole with crumbled tortilla chips or fried onions before baking for a satisfying crunch. This adds an irresistible texture contrast to the creamy casserole underneath.
Spice It Up: Feel free to increase the cayenne pepper or add sliced jalapeños for an extra kick. Making it spicy can be a fun way to cater to those who love a bit of heat!
Fresh Twist: Incorporate fresh herbs like parsley or cilantro before serving to brighten up the dish. A sprinkle of greens can elevate the presentation and add a burst of freshness.
Pasta Variations: Consider swapping the spaghetti for penne or rotini to change the pasta’s shape and texture. These alternatives can make the dish visually appealing and fun to eat.
Flavorful Base: Instead of cream of mushroom and chicken soup, try using a homemade creamy sauce or even a spicy tomato sauce for a different flavor direction. This can add depth and uniqueness to your casserole.
Savory Add-Ins: Mix in sun-dried tomatoes or olives for an extra pop of flavor. These ingredients bring a Mediterranean flare to your casserole, making it exciting and diverse.

For more comforting casserole inspirations, explore options like the delicious Cowboy Casserole or try something spicy with Fiery Chicken Ramen. Enjoy experimenting and making this dish your own!

What to Serve with Spicy Southern Chicken Spaghetti Casserole

Elevate your dining experience with delightful side dishes that beautifully complement this comforting casserole.

Mixed Greens Salad: A refreshing salad with a light vinaigrette adds a crisp contrast to the rich flavors of the casserole. The crunch of fresh greens balances the creamy layers.
Garlic Bread: Warm, buttery garlic bread is perfect for mopping up every last bit of cheesy goodness. Its crusty texture makes for a satisfyingly crunchy bite alongside the soft casserole.
Herb-Infused Rolls: Soft, pillowy rolls with fragrant herbs offer a delightful touch. These rolls can soak up the delicious sauce, making each taste more indulgent.
Roasted Vegetables: Oven-roasted seasonal veggies bring a burst of color and nutrition to your meal. The sweetness from the caramelization enhances the savory spaghetti flavors beautifully.
Macaroni and Cheese: For those who love extra comfort, a side of creamy mac and cheese amplifies the indulgence. The cheesy richness of both dishes creates a culinary feast.
Sweet Tea: This classic Southern drink is a perfect pairing with your meal. Its sweetness provides a delightful contrast to the spicy elements in the casserole, enhancing your overall dining experience.
Peach Cobbler: Finish off your meal with a warm peach cobbler. The sweetness of the fruit-filled dessert offers a delightful endnote to the savory casserole.
Cornbread: Lightly sweet cornbread pairs beautifully with the savory notes of the casserole, adding a Southern charm to your table. It’s great for absorbing those creamy sauces!
Cucumber and Tomato Salad: This light, refreshing salad can cool down the heat from the casserole while contributing a crisp texture. The acidity of the tomatoes and the crunch of the cucumbers provide a bright balance.

Storage Tips for Spicy Southern Chicken Spaghetti Casserole

Fridge: Store leftover Spicy Southern Chicken Spaghetti Casserole in an airtight container for up to 3 days. This keeps it fresh and ready for quick reheats!
Freezer: You can freeze the casserole in portioned containers for up to 2 months. Perfect for meal prep! Just thaw it overnight in the fridge before reheating.
Reheating: For best results, reheat leftovers in the oven at 350°F (175°C) for about 20 minutes, or until heated through, ensuring the cheese remains gooey.
Make-Ahead: Assemble the casserole and refrigerate it for up to 24 hours before baking. This makes it super convenient for last-minute meals!

Make Ahead Options

These Spicy Southern Chicken Spaghetti Casserole preparations are ideal for busy weeks! You can assemble the entire casserole and refrigerate it for up to 24 hours before baking. Simply prepare the mixture, transfer it to your greased baking dish, cover tightly with plastic wrap, and store it in the fridge. When you’re ready to enjoy this delicious comfort food, remove it from the fridge, uncover, and bake as directed, adding an extra 5-10 minutes to the baking time if it’s cold. To maintain the casserole’s creamy texture and delectable flavors, avoid overcooking, and let it rest for a few minutes before serving—ensuring every bite is just as delightful!

Tips for the Best Casserole

Even Shredding: Ensure your chicken is shredded evenly for consistent flavor distribution throughout the Spicy Southern Chicken Spaghetti Casserole.
Sauté Vegetables: If using fresh onions and bell peppers, sauté until soft to fully release their flavors. This will enhance the overall taste of the dish.
Rest Before Serving: Allow the casserole to rest a few minutes after baking to set properly before slicing. This step helps maintain its structure and makes serving easier.
Adjust Spice Levels: Feel free to adjust the cayenne pepper to your taste if you prefer less heat in your Spicy Southern Chicken Spaghetti Casserole.
Cheese Choices: Experiment with different cheese varieties for the topping—Monterey Jack or Pepper Jack can add a delightful twist to the flavor profile.

kfrirqz8f3vaombmbgvo

Spicy Southern Chicken Spaghetti Casserole Recipe FAQs

How do I choose the right chicken for this recipe?
Absolutely! It’s best to use cooked chicken that is shredded evenly to ensure all flavors are distributed throughout the Spicy Southern Chicken Spaghetti Casserole. You can also opt for rotisserie chicken for convenience, or use ground turkey or shredded tofu if you’re looking for alternatives. Just make sure it’s seasoned well for the best taste!

How should I store leftovers of the casserole?
Very good question! To store leftover Spicy Southern Chicken Spaghetti Casserole, place it in an airtight container in the refrigerator, where it will stay fresh for up to 3 days. When you’re ready to enjoy it again, simply reheat it in the oven at 350°F (175°C) for about 20 minutes until heated through and the cheese is wonderfully melty again.

Can I freeze this casserole?
Absolutely! You can freeze the Spicy Southern Chicken Spaghetti Casserole in portioned containers for up to 2 months. To freeze, just allow the casserole to cool completely, then cover it tightly with plastic wrap or foil before placing it in the freezer. When you’re ready to enjoy it, thaw it overnight in the refrigerator, then bake at 350°F (175°C) until heated through, about 25 to 30 minutes.

What should I do if my casserole is too dry after baking?
If you find your Spicy Southern Chicken Spaghetti Casserole is a bit dry after baking, it could be due to overbaking. Next time, try to keep an eye on it during the last few minutes! If it does happen, you can add a splash of chicken broth or a drizzle of cream over the top before reheating, which will help to reintroduce moisture.

Are there any dietary considerations for this casserole?
Definitely! If you’re serving those with dietary restrictions, you can easily adapt this recipe. To make it vegetarian, just substitute the chicken with a variety of veggies such as zucchini or spinach, and use plant-based soups. Additionally, check the cheese packaging for any dairy allergies—there are great non-dairy cheese options available that melt well. Always make sure to double-check ingredient labels to ensure they meet your specific dietary needs.

How long should I let the casserole rest before serving?
I often recommend letting the casserole rest for about 5-10 minutes after baking. This brief wait helps the layers set, making it easier to slice and serve. Plus, it allows the flavors to meld together just a little bit more, enhancing that yummy experience when you dig in!