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Spicy Southern Chicken Spaghetti Casserole

Spicy Southern Chicken Spaghetti Casserole for Cozy Nights

This Spicy Southern Chicken Spaghetti Casserole blends tender chicken and zesty spices in a creamy spaghetti dish perfect for cozy gatherings.
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Prep Time 15 minutes
Cook Time 30 minutes
Resting Time 5 minutes
Total Time 50 minutes
Servings: 6 servings
Course: Dinner
Cuisine: Southern
Calories: 450
Ingredients Equipment Method Nutrition Notes

Ingredients
  

For the Casserole
  • 2 cups Cooked Chicken You can substitute ground turkey or shredded tofu for a lighter option.
  • 12 oz Spaghetti Feel free to use penne or rotini instead.
  • 1 can Cream of Mushroom Soup 10.5 oz; switch to cream of celery for a different flavor profile.
  • 1 can Cream of Chicken Soup 10.5 oz; consider using a plant-based version for vegetarian option.
  • 1 can Diced Tomatoes with Green Chilies 10 oz; fresh tomatoes with chopped green chiles work well too.
  • 1.5 cups Shredded Cheddar Cheese Monterey Jack or Pepper Jack can be used for a kick.
  • 0.5 cup Chopped Bell Peppers Any color bell pepper will do.
  • 0.5 cup Chopped Onion Substitute with shallots for milder taste.
  • 1 tsp Garlic Powder Fresh garlic can be substituted in for a brighter taste.
  • 1 tsp Onion Powder Optional for lighter taste.
  • 0.5 tsp Paprika Swap with smoked paprika for extra punch.
  • 0.25 tsp Cayenne Pepper Adjust according to spice preference.
  • Salt and Pepper Customize to taste.
  • 2 tbsp Butter Olive oil is a good alternative.
  • Non-stick Cooking Spray Can be replaced with butter or oil for greasing.

Equipment

  • 9x13-inch baking dish
  • skillet
  • mixing bowl

Method
 

Step‑by‑Step Instructions
  1. Preheat your oven to 350°F (175°C) and grease a 9x13-inch baking dish with non-stick cooking spray or butter.
  2. In a skillet, melt 2 tablespoons of butter over medium heat, then sauté the chopped onions and bell peppers for about 5 minutes until tender.
  3. In a large mixing bowl, combine 2 cups of cooked chicken, sautéed vegetables, cream of mushroom soup, cream of chicken soup, and diced tomatoes. Mix in garlic powder, onion powder, paprika, cayenne pepper, salt, and pepper.
  4. Gently fold in 12 ounces of cooked spaghetti into the mixture.
  5. Pour the mixture into the greased baking dish, spreading it evenly.
  6. Sprinkle 1½ cups of shredded cheddar cheese over the top.
  7. Bake in the preheated oven for 25–30 minutes until the cheese is bubbly and golden brown.
  8. Let the casserole rest for a few minutes before serving.

Nutrition

Serving: 1servingsCalories: 450kcalCarbohydrates: 40gProtein: 30gFat: 20gSaturated Fat: 10gPolyunsaturated Fat: 2gMonounsaturated Fat: 6gCholesterol: 75mgSodium: 800mgPotassium: 600mgFiber: 3gSugar: 4gVitamin A: 500IUVitamin C: 40mgCalcium: 300mgIron: 2.5mg

Notes

For best results, allow casserole to rest before serving to maintain structure.

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