Preheat your oven to 350°F (175°C). Line a baking sheet with parchment paper.
In a large mixing bowl, combine the vegetable oil, ranch seasoning mix, red pepper flakes, garlic powder, and onion powder. Whisk until well blended.
Add the Cheez-Its to the bowl and gently toss them in the seasoning mixture until they are evenly coated.
Spread the coated Cheez-Its in a single layer on the prepared baking sheet.
Bake in the preheated oven for 10-12 minutes, stirring halfway through, until they are crispy and fragrant.
Remove from the oven and let them cool completely on the baking sheet before serving.