Preheat your oven to 350°F (175°C) and line a baking sheet with parchment paper.
In a large mixing bowl, combine the honey, Dijon mustard, vegetable oil, garlic powder, onion powder, salt, and black pepper. Whisk until well blended.
Add the pretzel bites to the bowl and toss them in the honey mustard mixture until they are evenly coated.
Spread the coated pretzels in a single layer on the prepared baking sheet.
Bake in the preheated oven for 15-20 minutes, stirring halfway through, until they are golden and crispy.
Remove from the oven and let cool for a few minutes before serving.